Covance Is Now Labcorp Drug Development
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The Local Lymph Node Assay (LLNA) is the gold standard nonclinical toxicology test for skin sensitization, namely to identify the immunogenic and allergenic properties of the active pharmaceutical ingredient (API).
In the test, rodent species are exposed to the API and examined after several days for T cell proliferation. LLNA measures the response of the lymph nodes to the API.
Sensitization is mediated by lymphocytes that recognize the API as a foreign substance and start to divide and increase in number. The LLNA provides a quantitative measurement.
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.
Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.
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