Covance Is Now Labcorp Drug Development
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OECD 492: EpiOcular™ is an in vitro reconstructed human corneal epithelium (RhCE) model used for an Eye Irritation Test (EIT) to assess ocular hazards of a test substance.
EpiOcular™ identifies chemicals not requiring classification and labeling for eye irritation or serious eye damage by determining cell damage, namely cytotoxic effects. This is based on the premise that all such substances will induce cytotoxicity in the corneal epithelium and/or conjunctiva and is in accordance with the United Nations Globally Harmonized System (UN GHS).
Studies have found EpiOcular™ to have an overall accuracy of 80 %. Test substances can be applied topically, so tissue exposures occur just as they do in vivo.
OECD 493: Human recombinant estrogen receptor (hrER)
OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
OECD 439: In vitro skin irritation (EpiSkin™ / EpiDerm™)
OECD 442E: Human cell line activation test (h-CLAT)
OECD 455: Estrogen receptor transcriptional activation (ERTA)
OECD 435: In vitro skin corrosion (Corrositex®)
OECD 456: H295R Steroidogenesis assay
OECD 437: BCOP (bovine corneal opacity permeability)
Cytoxicity assays for ISO/ICCVAM/HC: Balb/c C3T3; L929; MRC5
OECD 492: Ocular irritation and EpiOcular™ (in vitro)
OECD 431: In vitro skin corrosion (3D model)
OECD 438: Isolated chicken eye test (with optional histopathology)
Eye irritation
OECD 432: In vitro phototoxicity (Balb/c 3T3)
OECD 442D: KeratinoSens™ assay
About our nonclinical animal research models: We provide the utmost care for our research animals and actively pursue advances in animal welfare. As well as ensuring the highest scientific, ethical and regulatory standards, selection of appropriate animal research models for development research is critical to developing safe and effective treatments, devices and products that protect and save lives. Just as we have ethical committee oversight for human trials, we have ethical committees overseeing all aspects of our global animal care and use programs. All of our core, nonclinical facilities are accredited by AAALAC. Learn more about our commitment to replacing, reusing and refining nonclinical research models.
Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.
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