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OECD 492: Ocular irritation and EpiOcular™ (in vitro)
OECD 492: EpiOcular™ is an in vitro reconstructed human corneal epithelium (RhCE) model used for an Eye Irritation Test (EIT) to assess ocular hazards of a test substance.
EpiOcular™ identifies chemicals not requiring classification and labeling for eye irritation or serious eye damage by determining cell damage, namely cytotoxic effects. This is based on the premise that all such substances will induce cytotoxicity in the corneal epithelium and/or conjunctiva and is in accordance with the United Nations Globally Harmonized System (UN GHS).
Studies have found EpiOcular™ to have an overall accuracy of 80 %. Test substances can be applied topically, so tissue exposures occur just as they do in vivo.
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OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
Genetic, Acute, In Vitro Alternate -
Eye irritation
Genetic, In Vitro Alternate, Acute -
OECD 432: In vitro phototoxicity (Balb/c 3T3)
Toxicology, In Vitro Alternate -
OECD 439: In vitro skin irritation (EpiSkin™ / EpiDerm™)
Toxicology, In Vitro Alternate -
OECD 493: Human recombinant estrogen receptor (hrER)
In Vitro Alternate -
OECD 442E: Human cell line activation test (h-CLAT)
Toxicology, In Vitro Alternate -
OECD 455: Estrogen receptor transcriptional activation (ERTA)
Toxicology, Endocrine, In Vitro Alternate -
OECD 435: In vitro skin corrosion (Corrositex®)
Toxicology, In Vitro Alternate -
OECD 456: H295R Steroidogenesis assay
Toxicology, Endocrine, In Vitro Alternate -
OECD 437: BCOP (bovine corneal opacity permeability)
Toxicology, In Vitro Alternate -
OECD 438: Isolated chicken eye test (with optional histopathology)
Toxicology, In Vitro Alternate -
Cytoxicity assays for ISO/ICCVAM/HC: Balb/c C3T3; L929; MRC5
Toxicology, In Vitro Alternate -
OECD 492: Ocular irritation and EpiOcular™ (in vitro)
Toxicology, In Vitro Alternate -
OECD 442D: KeratinoSens™ assay
Toxicology, In Vitro Alternate -
OECD 431: In vitro skin corrosion (3D model)
Toxicology, In Vitro Alternate
