OECD 493: Human recombinant estrogen receptor (hrER)
Labcorp is a leading global life sciences company that includes contract research and developmental services to the pharmaceutical, medical technology, crop protection and chemical industries.
OECD 492: EpiOcular™ is an in vitro reconstructed human corneal epithelium (RhCE) model used for an Eye Irritation Test (EIT) to assess ocular hazards of a test substance.
EpiOcular™ identifies chemicals not requiring classification and labeling for eye irritation or serious eye damage by determining cell damage, namely cytotoxic effects. This is based on the premise that all such substances will induce cytotoxicity in the corneal epithelium and/or conjunctiva and is in accordance with the United Nations Globally Harmonized System (UN GHS).
Studies have found EpiOcular™ to have an overall accuracy of 80 %. Test substances can be applied topically, so tissue exposures occur just as they do in vivo.
OECD 493: Human recombinant estrogen receptor (hrER)
OECD 442C: Direct peptide reactivity assay (DPRA) for skin sensitization
OECD 439: In vitro skin irritation (EpiSkin™ / EpiDerm™)
OECD 442E: Human cell line activation test (h-CLAT)
OECD 455: Estrogen receptor transcriptional activation (ERTA)
OECD 435: In vitro skin corrosion (Corrositex®)
OECD 456: H295R Steroidogenesis assay
OECD 437: BCOP (bovine corneal opacity permeability)
Cytoxicity assays for ISO/ICCVAM/HC: Balb/c C3T3; L929; MRC5
OECD 492: Ocular irritation and EpiOcular™ (in vitro)
OECD 431: In vitro skin corrosion (3D model)
OECD 438: Isolated chicken eye test (with optional histopathology)
Eye irritation
OECD 432: In vitro phototoxicity (Balb/c 3T3)
OECD 442D: KeratinoSens™ assay